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Ozanimod causes lymphocyte retention in lymphoid tissues.
The mechanism by which ozanimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve the reduction of lymphocyte migration into the central nervous system.
Ultimately, the nerves themselves may deteriorate — a process that's currently irreversible. RMS is characterized by clearly defined attacks of worsening neurologic function.The secondary MRI endpoints included the number of new or enlarging hyperintense T2-weighted brain MRI lesions over 12 months, number of gadolinium-enhanced brain MRI lesions at month 12 and percent change from baseline in whole brain volume at month 12.Cortical grey and thalamic volume changes were also prospectively assessed versus active comparator.The study included 1,320 people living with RMS across 150 sites in 21 countries.The primary endpoint of the trial was ARR over 24 months.